Crimean-Congo Hemorrhagic Fever: Epidemiology, Pathogenic Mechanism, Treatment Approaches, Prevention and Control Strategies – Biological Times

Crimean-Congo Hemorrhagic Fever: Epidemiology, Pathogenic Mechanism, Treatment Approaches, Prevention and Control Strategies

Publication Date : 07/01/2024


Author(s) :

Samran Ahmad, Muhammad Sohaib Tahir, Muhammad Shehroz Sarfraz, Muhammad Mudassar Javed, Abdullah.


Volume/Issue :
Volume 2
,
Issue 12
(01 - 2024)



Abstract :

Crimean-Congo hemorrhagic fever is a tick-borne viral zoonotic disease. Various domestic and wild animals serve as reservoir host. It infects humans by tick bites or handling of infected live infected stock. CCHF is found in many countries in Africa, Asia, Eastern Europe and Central Asia with case fertility rate of more than 30% in many regions. It was initially identified in the Crimean region of Russia in 1944 later in the Congo basin in 1967, and its first case in Pakistan was reported in 1976 in Rawalpindi. It is highly infective virus and have no specific treatment usually affecting host immune system making it susceptible to many other diseases. Many supportive treatments are used for its treatment like ribavirin, monoclonal antibodies and some corticosteroids. The main ways to prevent CCHF are to maintain hygiene practices. The main purpose of this review is to develop better understanding of the epidemiology, pathogenesis and prevention of CCHF virus as it is a serious zoonotic disease from past two decades and there is no appropriate animal model to study the disease.


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