Author(s) :

Khadija Riaz, Dr. Sidra Altaf *, Tasawar Iqbal, Dr. Muhammad Zia .

Volume/Issue :

Abstract :

Aplastic anemia (AA) is characterized by abnormalities in stem and progenitor cells, bone marrow cytopenia, and peripheral blood pancytopenia. This condition mainly affects children, teenagers, and people aged 60 or above. Bone marrow is a porous substance found in the medullary cavity of the skeletal elements, primarily in the vertebrae, pelvis, and lower extremities. Bone marrow contains stem cells. Stem cells can self-renew, create more stem cells, and develop into different cell types like erythrocytes, leukocytes, and platelets. In acquired aplastic anemia, there is a severe deficiency of blood elements and subsequent reduction in levels of red blood cells, white blood cells and platelets.

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3