Author(s) :

Arslan Muhammad Ali Khan.

Volume/Issue :

Abstract :

The effectiveness of practically all available medicines has decreased due to the rising prevalence of drug resistance in Mycobacterium tuberculosis (TB), hampering efforts to stop the spread of this global health threat. To increase treatment efficacy and stop the emergence of antibiotic resistance, optimal drug combinations are required in addition to the discovery of new medications. Antibiotic resistance often results in decreased sensitivity, but occasionally, drug resistance evolution can result in increased sensitivity to unrelated medicines. Collateral sensitivity in M. tuberculosis is mainly unstudied, although it suggested alternate approaches to fight drug-resistant forms that are resistant to present treatments. Here, the mechanism of resistance in M. tuberculosis and a combination of therapy against this particular pathogen has been explained. Keywords: M. tuberculosis, Resistance, Drugs

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