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Naegleria fowleri, belonging to Percolozoa phylum (thermophilic), is an ameboflagellate and eukaryotic, free-living amoeba that is responsible for affecting the nervous system and brain-causing primary amoebic meningoencephalitis (PAM), and sub-acute or chronic granulomatous amebic encephalitis two severe waterborne diseases. This amoeba, belonging to the unique genera of free-living amoebae (FLA), can lead to opportunistic or non-opportunistic infections in humans, affecting the brain, skin, or cornea. N. fowleri is commonly found in lukewarm environments such as lakes, streams, spas, pools, domestic water reservoirs, heating and air conditioning units, and water supplies. It can lead to death within a 10-day cycle. This amoeba doesn't form a cyst inside the body. While water is the primary transmission route for PAM, there's also a potential alternative route through dust.
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