Author(s) :

Nabeela Jabeen, Fariha Munir, Fizza Riaz, Noor ul ain Arshad , Saleha Tahir.

Volume/Issue :

Abstract :

The Plasmodium spp. parasite causes malaria that infects vertebrates and is spread via female Anopheles mosquito bites. The Plasmodium species leading to malaria in humans are not monophyletic; they have common ancestors with parasites that infect nonhuman primates. Every year, there are 300–500 million cases of malaria worldwide. Plasmodium falciparum is mostly responsible for the 1.5 - 2.3 million deaths due to malaria that occur each year. Coordinated regulation of gene expression is necessary for Plasmodium falciparum's complex life cycle in order to facilitate host cell invasion, transmission, and immune evasion. A potential strategy to stop transmission would involve using a mix of long-acting gametocidal and fast-acting schizontocidal medications. Research is still being done to develop better diagnostic techniques, create therapies that work, and put in place long-term programs to manage and eradicate malaria. In this study, we review P. falciparum transmission by discussing gametocyte targetable features and offering a prediction on a forward-genetic method for future identification of novel candidates that block transmission.

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