Author(s) :

Madiha Sarfraz, Minha Batool, Maryam Zahid, Noor Hyder, Khadija Majeeb, Saleha Tahir.

Volume/Issue :

Abstract :

Alzheimer's dementia is the most prevalent neurodegenerative illness, is quickly becoming as a major global public health issue. Since there is currently no treatment, prevention remains the primary focus despite years of research into various therapeutic options. The clinical and physiological phases of the AD spectrum are updated in this review, along with treatment limitations, research models utilized in AD, and risk factors for AD therapy. The method of distributing drugs to the central nervous system is still complex, which makes developing therapeutic and preventative strategies challenging. Novel approaches to improving the brain's chemical absorption capacity are being studied. According to recent neuropathological, biochemical, and neuroimaging studies, 20% to 30% of older adults who are cognitively healthy have biomarkers of AD in their brains and cerebrospinal fluid (CSF), highlighting the need of early AD detection. This article lists gene therapy, immunotherapy, and quantum dots as advancements in Alzheimer's disease treatment methods and outlines current views on the illness's etiology. The future of Alzheimer's disease treatment is believed to lie in brain imaging, theranostics, artificial intelligence, and biomarkers.

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