Author(s) :

Madiha Sarfraz , Saifuddin, Tania Rasham, Tamsal Murtza, Saleha Tahir.

Volume/Issue :

Abstract :

Pseudomonas aeruginosa belongs to the family of Gram-negative bodied bacterium and it’ll infect an immunocompromised person. It is referred to as the cardinal cause of mortality and morbidity among the patients who suffer from cystic fibrosis and also as one of the cardinal sources of hospital acquired infections. Due to various forms of adaptation, resistance to various classes of antibiotics that may be used to treat infections causing organisms, infections caused by P. aeruginosa are dangerous and can even be life threatening. This brings a significant challenge in clinically; mainly because of its multiple antibiotic-resistant mechanisms, biofilm producing capability, and its ability to cause chronic infection in both animals and humans. This review provides strategies intended for managing P. aeruginosa or preventing its infections which include: Conventional antibiotics are quashed much of the time but are quickly becoming ineffective due to newly formed multidrug-resistant bacteria. P. aeruginosa is naturally endowed with resistance to antibiotics and various forms of antibiotic resistance mechanisms will be highlighted in this work. Therefore, besides the antibiotics, the action strategies such as quorum sensing inhibition and alternative therapies such as phage therapy and nanoparticle-based therapy are further being worked out.

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