Author(s) :

MUHAMMAS SAJID, Muhammad Azam, Ayesha, Muhammad Ibtisam Elahi, Maryam Bakhat.

Volume/Issue :

Abstract :

Active investigations into the resistome have been conducted since the inception of the antibiotic resistome concept just over a decade ago. In this study, we revisit the established notion of the resistome, encompassing all forms of antibiotic resistance genes (ARGs), alongside significant findings from each One-Health domain that has embraced this concept. This underscores the pivotal role of the One-Health approach in understanding the dissemination of ARGs. The intricate architecture of the resistome, as observed in the microbiomes of humans, animals, and the environment, necessitates scrutiny through cutting-edge research methodologies. Proposed future directions for resistome research aim to enhance comprehension and management of ARG transmission, building upon recent achievements in resistome studies across various One-Health sectors. These directions include: (1) prioritizing critical ARGs and their associated hosts; (2) elucidating ARG transmission dynamics at the interfaces of One-Health sectors; (3) pinpointing selective pressures influencing the emergence, propagation, and evolution of ARGs; and (4) unraveling the mechanisms facilitating organismal traversal of taxonomic barriers in ARG transmission. Keywords: Antibiotic Resistance, One Health, Microbiomes, Cutting-edge technologies.

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