Author(s) :

Muneeb Ur Rahman, Habiba Akram .

Volume/Issue :

Abstract :

Clinical trials on male contraceptives have shown significant progress, with innovative hormonal formulations demonstrating high efficacy in suppressing spermatogenesis. Studies since the 1970s have explored various methods and biological agents, including testosterone enanthate, cypionate, and undecanoate, often combined with progestins, achieving azoospermia in up to 95% of men. Recent trials with new hormonal entities like dimethandrolone undecanoate and segesterone acetate are promising, with phase II trials ongoing. Despite these advancements, acceptance and access remain challenges. Side effects such as acne, weight gain, and mood changes have been reported, but they are generally reversible. Ensuring the development of effective, reversible, and safe male contraceptives is crucial for comprehensive family planning. The current research aims to address these issues, with results from large-scale studies expected by late 2024. This article highlights the significant advancements and ongoing efforts in clinical trials to enhance the efficacy and acceptance of male contraceptives.

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