Author(s) :

Maheen Khalid, Iqra Jabeen, Musaffa Imran, Ume Areeba, Rabia Khalid.

Volume/Issue :

Abstract :

The general health and the immune system rely on the bacteria in the gut. There are numerous neuroscientific studies that have shown the significance of bacteria in brain systems formation. It is well demonstrated that the microbial ecology of the gastrointestinal tract is connected with the anxiety and depression disorders. Most of the anxiety disorders are incapacitating and current. An increasing amount of evidence shows that changes in the composition and activity of the gut microbiota caused by diet affect anxiety symptoms and threat through metabolic, neurological, and endocrine pathways. The review is a synthesis of clinical and molecular evidence that puts anxiety disorders as associated with probiotic, prebiotic, and synbiotic treatments, microbial genera and metabolites (particularly, short-chain adipose acids), and whole-diet research. The clinical and translational evidence has shown that plant-forward, high-fiber diets and particular psychobiotics reduce the symptoms of anxiety, but those should be interpreted with caution because of the differences in the strains, dosages, study group, and short-term follow-up. Future studies should include large, phenotyped RCTs incorporating microbiome, metabolomic, and neuroimaging end points to come up with accurate dietary recommendations based on microbiomes to prevent anxiety and adjunctive care.

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