Author(s) :

Areeka Batool, Bushra Sadia, Imshal Azam, Amara Zafar, Muhammad Asif, Saleha Tahir.

Volume/Issue :

Abstract :

Cerebral palsy (CP) is an incapacitating condition that lasts throughout life in impairments of movement and posture whose etiopathogenesis involves genetic, prenatal, neonatal, and postnatal factors. Different levels of severity are there in each case, so they need long-term follow-up and inputs to improve functional outcomes and quality of life; treatment has mainly been targeted towards symptom-management. New developments in the biotechnological field, such as stem cell therapy and nanoparticle-based drug delivery, hold promises for the future. Stem cell therapy could act as a neuroprotective and reparative agent by promoting neurogenesis, synaptic plasticity, and modulating inflammation. Nanoparticle-based drug delivery through dendrimers is particularly promising, since they will enable drugs to cross the blood-brain barrier, improve efficacious treatment, and better the overall therapeutic approaches. Such emerging therapies give more faith that effective treatments may evolve on the horizon, elucidating avenues for breakthrough in cerebral palsy management. This review will focus on their emerging therapeutic approaches and the possible future advancement of CP management.

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