Author(s) :

Javeria, Aiman Irfan, Tasawar Iqbal, Sidra Altaf.

Volume/Issue :

Abstract :

Undetermined etiology and unknown cause are both synonymous with the term autoimmune disease. It is the very reason behind the occurrence of synovial inflammation and subsequently joint erosion in cases of rheumatoid arthritis. Recent literature has provided plenty of evidence that places exosomes as key players in the pathogenesis of RA, and as such, they might be employed as biomarkers or therapeutic nanocarriers. Due to the fact that exosomal content includes miRNAs, cytokines, and proteins, this indicates that it contributes to the activation of synovial fibroblasts and immune regulation through inflammatory pathways. The presence of these exosomes in the blood and fluid of major joints makes them a good indicator of early diagnosis and monitoring advancement of diseases. Thereafter, newer methodologies have been developed over time, such as molecular docking and bioinformatics, to comprehend the interactions of exosomes in coming years, opening new horizons for therapy.

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