Author(s) :

Muhammad Munir Shah, Atiq Ullah, Mudasir Khan, Tanveer Ahmed Malik, Asma Amjad, Akmal Ali, Muhammad Usman.

Volume/Issue :

Abstract :

Chickens raised in commercial settings are susceptible to many environmental diseases. Therefore, to prevent the occurrence of infectious diseases, the flock must be regularly vaccinated. Effective adjuvants that enhance protection and do not result in any unintended adverse reactions when given to birds in conjunction with the vaccine are necessary for the fight against infectious illnesses. In light of this viewpoint, there is a greater need for improved vaccination adjuvants that work. Efforts are underway to improve vaccine effectiveness by using appropriate adjuvants, especially those based on the Toll-like receptor (TLR). Pattern recognition receptors (PRRs) that can identify conserved pathogen compounds include TLRs. Numerous investigations have confirmed flagellin's efficacy as an adjuvant and its capacity to stimulate the production of cytokines by various innate immune cells. Our present knowledge of flagellin action, its function in triggering a cytokine response in chicken cells, and its possible application as an adjuvant in chicken vaccines, both alone and in conjunction with other TLR ligands, are compiled in this mini-review.

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