Author(s) :

Tasawar Iqbal, Nadeem Ahmed , Abdur Rehman, Sidra Altaf.

Volume/Issue :

Abstract :

Chromosomal defects involve genetic alterations that are caused by abnormal cell division. Often, such errors result in either numerical or structural changes in chromosomes. Structural abnormalities may very rarely result in a disorder caused by meiotic division. The most important types are trisomy, such as Down syndrome, and monosomy, such as Turner syndrome. Contrary to this, mitotic abnormalities may happen in embryos during development. In fact, long lists of things can cause such abnormalities advanced age, environmental causes like radiation or exposure to other chemicals, genetic makeup. Some abnormalities are hereditary, while others occur spontaneously from denovo mutations. Chromosomal abnormalities have been one of the largest risk categories in developmental disorders, infertility, and cancer. Current research is going on to ameliorate genetic therapies and preventive strategies. It is highly important mechanisms of chromosomal abnormalities for early detection, genetic counseling, and potential treatments in future.

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