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Feline Calicivirus (FCV) is a highly contagious viral pathogen that has significant health implications for domestic cats, particularly in areas where large numbers of animals are housed, such as shelters and catteries. It plays a significant role in causing upper respiratory sero-infection in cats, and it may present in various forms, ranging from mild to severe and progressive systemic illness. The virus's infamousness can be highlighted by its resistance to environmental degradation and the high rates of mutation, leading to the development of many strains with different degrees of virulence. Clinical findings supported with lab testing usually diagnose the case, and treatment is rather supportive, covering symptoms and secondary infection. Even with regular immunization, full protection cannot be achieved because of the genetic flexibility in this virus. Commendable control implies the combined strategy of vaccination, proper hygiene, early isolation of diseased animals, and proper management practices. Epidemiology, pathogenesis, clinical findings, specific diagnosis solutions, therapeutic regimes, and preventative measures against FCV are reviewed.
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