Author(s) :

Muhammad Izhar, Sahar Riaz, Musharraf Manzoor, Muhammad Rehan Khalid, Saira Riaz, Ayesha Bintay Farooq.

Volume/Issue :

Abstract :

Rabies is a disease that infects the central nervous system and causes serious brain damage. The disease is usually spread by the bite of infected animals, specifically stray dogs. Rabies virus (RABV) exists in all territories except Antarctica and Australia, and it is the cause of death of approximately 60,000 people per year. As the virus enters the body, it first multiplies in muscle tissue, then enters nerve cells through muscle tissue and proceeds to the brain via rapid axonal transport. RABV destroys brain cells and interrupts their normal functioning. The disease has five stages and is manifested in furious and paralytic forms. The structural proteins N, P, M, and G of the virus help in evading the immune system after interrupting the antiviral responses, reducing inflammation, and keeping the blood-brain barrier intact. The study of these mechanisms is important, as it is needed to enhance treatment and reduce the chances of this neurotropic virus.

No. of Downloads :

14