Author(s) :

Sarosh Zameer, Own Nasir , Bilal Iftikhar, Rubab Hussain Awan, Aaiza.

Volume/Issue :

Abstract :

Newcastle disease virus (NDV) is a part of the avulaviridae family. It is a significant avian pathogen, including lentogenic (low pathogenicity), mesogenic (moderate), and velogenic (high-pathogenicity) strains. Velogenic strains pose an extreme danger to poultry due to systemic infection and a high mortality rate, and cause mild conjunctivitis or flu-like symptoms among poultry workers. In poultry, both live attenuated (LaSota strain) and inactivated NDV vaccines are widely used. NDV has been used in human medicine as an oncolytic virus due to its selective replicative property and breakdown of cancer cells while stimulating antitumor immunity. Rapid and accurate diagnosis is important for disease control, utilizing techniques including virus isolation, hemagglutination inhibition assays, ELISA, and RT-PCR to differentiate and control outbreak management. Emerging advancements in recombinant NDV vaccines and viral vector technologies offer promising platforms for the improvement of vaccine efficacy and expanding applications in both veterinary and human health.

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