Articles

Veterinary biologics, including vaccines, immunomodulators, and monoclonal antibodies, are important tools to help predict the potential for immunity in humans from a One Health perspective. Using epidemiological data based on natural exposure allows for the approximate creation of human-like immunological responses that could not be obtained from clinical controlled trials. Data such as antibody kinetics, cellular activation, and correlates of immunity allow researchers to establish human immunological characteristics from studies in veterinary medicine. Comparative study of multiple species confirms that immunological pathways and biomarker systems for vaccine performance are conserved across species. Zoonotic disease case studies show the importance of veterinary investigations in determining potential human health risks and vaccine development. Despite species-specific differences, veterinary epidemiological data, along with systems immunology and predictive modeling, give accurate forecasts of immune responses.