Articles

“Escherichia coli Nissle” is a probiotic strain, which is engineered to administer drugs and proteins locally, reducing drug degradation and dilution, and for target-specific therapy. There are 4 Methods discussed here: “Outer Membrane Vesicles” OVMs, Curli fiber-mediated for inflammatory gut disease, and Targeted expression of certain recombinant gene upon detection of certain chemical signals, and lastly, Bacterial Ghost for administration of Antibodies and Antigen safely, and for previously deemed ineffective drugs due to its structural similarity to ineffective anti cancerous drug. This might seem like a cheat code in diagnosis and treatment, but it can be pathogenic for immunocompromised ones, can disrupt the genome of normal host cells, can cause toxicity, and can become resistant to antimicrobials due to horizontal gene transfer.