Articles

Crimean–Congo Hemorrhagic Fever (CCHF) is a life-threatening disease transmitted by ticks, posing a significant public health challenge in regions where it is prevalent. Understanding how the CCHF virus replicates is essential for developing effective treatments, but working with the virus in laboratories requires strict safety precautions due to its high risk. To overcome these limitations, researchers increasingly rely on computational approaches that allow them to study the virus safely, efficiently, and at lower cost. This project employed several computer-based strategies, including comparing viral genetic sequences, modeling protein structures, predicting potential drugs to disrupt viral-host interactions, and applying systems biology to explore the roles of viral proteins in genome replication. Findings from these approaches have deepened our knowledge of viral replication mechanisms and identified potential targets for antiviral therapies. Overall, this study highlights that computational methods are powerful tools for advancing CCHF research and guiding future drug development efforts.