Articles

Nipah virus (NiV) is a new virus that is a serious threat to public health and global security because it has a high mortality rate and can spread rapidly between people. In this paper, we will summarize our current knowledge of NiV virology, including how NiV enters human hosts, replicates, evades the immune response, and causes disease. A primary focus will be placed on the unique molecular basis for NiV's clinical manifestations, which include the specificity of NiV infection to endothelial and neuronal cells, the dysregulated immune response of the human host, the presence of virulence factors that are unique to each strain of NiV, and the failure of the host immune system to generate an effective immune response to eliminate NiV from the human body. Furthermore, recognizing the global public health threat of NiV infection and its implications for global health security emphasizes the need for innovative and proactive surveillance strategies to reduce the hazards associated with this zoonotic viral pathogen.