Articles

The Brain-Gut-Skin Axis (BGSA) is a complex bidirectional communication network in which psychological well-being and intestinal health directly influence skin health. There exists a strong connection between mental conditions, gut microbiome composition, and skin disorders. Studies have shown that people with skin inflammatory conditions also experience mental conditions like depression, along with gastrointestinal (GI)tract issues like bloating, constipation, etc. These clinical signs highlight the connection between brain, gut, and skin conditions. Dysbiosis disrupts normal physiology; thus, to maintain it, therapeutic interventions are suggested in this article. The postbiotics are emerging as a more stable and safe therapeutic alternative. Examples of the compounds that act as postbiotics and have shown promising results in treating inflammatory conditions such as atopic dermatitis (AD) and acne are: short-chain fatty acids (SCFAs), extracellular polysaccharides, microbial cell fragments, cell lysates, vitamins, and teichoic acid. In recent years, a thorough understanding of BGSA and the use of emerging compounds like postbiotics is essential for eradicating the inflammatory skin conditions from their root.